Death of William Knowles (American chemist, Nobel laureate 2001), June 13. William Knowles was a prominent American chemist recognized for his pioneering work in asymmetric synthesis and the development of metal catalysts for chemical reactions. In 2001, he was awarded the Nobel Prize in Chemistry alongside Ryōji Noyori and Barry Sharpless for his significant contributions to the creation of highly pure pharmaceutical and industrial compounds. Throughout his career, Knowles made a substantial impact on the pharmaceutical industry and organic chemistry. One of his major achievements was the invention of catalytic processes that enabled the production of drugs with specific isomers, improving both the quality and effectiveness of medications. These innovations in the late twentieth century opened new avenues in chemical research and led to the development of more effective pharmaceuticals. William Knowles passed away on June 13, 2012. His death marked a notable moment in the global scientific and chemical community, highlighting his role in scientific advancement. In 2012, several scientific institutions and universities commemorated his legacy through memorial events and the publication of specialized articles. The inclusion of this date in the Gregorian calendar was made after his death in 2012 by academic and scientific communities, specifically to honor Knowles's contributions to the advancement of chemistry.